Killers is a 2010 American comedy film starring Katherine Heigl and Ashton Kutcher. The film was released in the United States and Canada on June 4, 2010. The film centers on a young woman who meets a guy who turns out to be a CIA assassin.

The Last Airbender is a 2010 adventure fantasy film released on July 1, 2010. The movie combines live action and Computer animation to create this film adaptation based on the first season of the animated television series Avatar: The Last Airbender.

The film stars Noah Ringer as Aang, and also stars Nicola Peltz, Jackson Rathbone, and Dev Patel.

The Last Airbender was produced by Paramount Pictures and Nickelodeon Movies. Development for a film began in 2007; it was adapted into a film by M. Night Shyamalan, who also directed and produced. Other producers include Frank Marshall, Kathleen Kennedy, Sam Mercer and Scott Aversano. The series from which it was adapted was influenced by Asian art, mythology and various martial arts fighting styles and was created by Michael Dante DiMartino and Bryan Konietzko. Filming began in mid-March 2009, with locations in Greenland and Pennsylvania.

The Last Airbender was made for $150 million and marketed with a budget of $130 million, making total costs at least $280 million. Premiering in New York City on June 30, 2010, it opened in the United States the following day, grossing an estimated $16 million. The Last Airbender opened in second place at the box office behind The Twilight Saga: Eclipse, and eventually grossed $131 million domestically and $318 million worldwide. The film was widely panned by both critics and audience, especially fans from the original series.

Despite its successful box-office performance, the Razzie Award for Worst Picture was presented to The Last Airbender in 2011 making it the second year in a row that a blockbuster has received this award after the previous year's recipient Transformers: Revenge of the Fallen.

Sex and the City 2 (also known as SATC2) is a 2010 American romantic comedy film, the sequel to the 2008 film Sex and the City, which is based on the HBO TV series of the same name.

The film was released in cinemas on May 27, 2010 in the United States and May 28, 2010 in the United Kingdom. The DVD was available for purchase in the United Kingdom on 29 November, 2010. The film stars Sarah Jessica Parker, Kim Cattrall, Kristin Davis, Cynthia Nixon, and Chris Noth, who reprised their roles from the previous film and TV series. It also features cameos from Liza Minnelli, Miley Cyrus, Tim Gunn, and Penélope Cruz.

The Twilight Saga: Eclipse, commonly referred to as Eclipse, is a 2010 American romantic vampire film based on Stephenie Meyer's 2007 novel, Eclipse. It is the third installment of The Twilight Saga film series, following 2008's Twilight and 2009's New Moon. Summit Entertainment greenlit the film in February 2009. Directed by David Slade, the film stars Kristen Stewart, Robert Pattinson, and Taylor Lautner, reprising their roles as Bella Swan, Edward Cullen, and Jacob Black, respectively. Melissa Rosenberg, who penned the scripts for both Twilight and New Moon, returned as screenwriter. Filming began on August 17, 2009, at Vancouver Film Studios, and finished in late October, with post-production began early the following month. Bryce Dallas Howard was cast as Victoria, replacing Rachelle Lefevre who previously played her.

The Bounty Hunter is a comedy film directed by Andy Tennant, starring Jennifer Aniston and Gerard Butler. The story centers on a bounty hunter (Butler) hired to retrieve his ex-wife (Aniston) who has skipped bail. The film was released in the United Kingdom and United States on March 19, 2010.

Vampires Suck is a 2010 American vampire spoof film based on the Twilight film series and directed by Jason Friedberg and Aaron Seltzer. It stars Jenn Proske, Matt Lanter, Christopher N. Riggi, Ken Jeong, and Anneliese van der Pol

Valentine's Day is a 2010 American romantic comedy film directed by Garry Marshall. The screenplay was written by Katherine Fugate from a story by Fugate, Abby Kohn and Marc Silverstein.

The Last Song is a 2010 American coming of age drama film developed alongside Nicholas Sparks novel by the same name. The film was directed by Julie Anne Robinson in her feature film directorial debut and co-written by Sparks and Jeff Van Wie. The Last Song stars Miley Cyrus, Liam Hemsworth, and Greg Kinnear and follows a troubled teenager as she reconnects with her estranged father and falls in love during a summer in a quiet Southern United States beach town. The film is distributed by Touchstone Pictures.

Little Fockers (known as Meet the Parents: Little Fockers in the United Kingdom and Southeast Asia) is a 2010 American comedy film and sequel to Meet the Parents (2000) and Meet the Fockers (2004). It stars Robert De Niro, Ben Stiller, Owen Wilson, Blythe Danner, Teri Polo, Dustin Hoffman and Barbra Streisand. The first film in the series not to be directed by Jay Roach, it is instead directed by Paul Weitz with Roach as one of the producers. Likewise Stephen Trask, a relative newcomer, takes over composing duties from veteran Randy Newman. In addition to the original cast, Little Fockers features Jessica Alba, Laura Dern and Harvey Keitel.

Clash of the Titans is a 2010 fantasy film and remake of the 1981 film of the same name (the rights to which had been acquired by distributors Warner Bros. in 1996). As with the 1981 film, the story is very loosely based upon the Greek myth of Perseus. Directed by Louis Leterrier and starring Sam Worthington, the film was originally set for standard release on March 26, 2010. However, it was later announced that the film would be converted to 3D and was released on April 2, 2010.